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Effects of traditional medicines, Gosya‐jinki‐gan, “Kyushin” and “Reiousan” on sexual and learning behaviour in chronically stressed mice
Author(s) -
Morishita ShinIchi,
Shoji Masamichi,
Oguni Yasuhiro,
Hirai Yasuharu,
Sugimoto Chishio,
Ito Chihiro
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070217
Subject(s) - licking , extinction (optical mineralogy) , memory impairment , sexual behavior , medicine , impaired memory , developmental psychology , neuroscience , psychology , pharmacology , biology , cognition , paleontology
Traditional medicines, such as Gosya‐jinki‐gan (Niu‐Che‐Shen‐Qi‐Wan) extract preparation (KJE), “Kyushin” (KY–2) and “Reiousan” (R–03) were studied to determine their effects on sexual and learning behaviour in mice subjected to chronic “hanging stress”. Drugs were given orally once a day for 14 days, and sexual (licking, mounting and intromission) and learning (memory retrieval and memory extinction) behaviour were observed. KJE and R–03 protected mice against the stress‐induced decrease of licking, mounting and intromission behaviour, and increases of acceleration of memory loss and failure of memory retrieval. KY–2 protected mice against stress‐induced decrease of licking and intromission behaviour, and increases of acceleration of memory loss and failure to retrieve memory. These results suggest that these drugs have protective effects against chronically exhausted states.