Premium
Quercetin and naringenin; effects on ulcer formation and gastric secretion in rats
Author(s) -
Martin M. J.,
Motilva V.,
ÓN de la Lastra C. Alarc
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070211
Subject(s) - naringenin , quercetin , histamine , ulcer index , pepsin , gastric secretion , medicine , gastroenterology , secretion , flavonoid , pharmacology , chemistry , gastric mucosa , stomach , biochemistry , enzyme , antioxidant
The antiulcerogenic effect of two flavonoids, quercetin and naringenin, in acute gastric ulcer (cold‐restraint and pylorus‐ligated) has been investigated. In both models quercetin and naringenin presented a significant decrease in ulcer index with respect to the control group. Nevertheless, in the Shay‐ligated method no decrease in either volume, acidity or pepsin were observed, however, a significant difference was found in histamine secretion values.