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Stimulation of tissue repair by Mikania cordata root extract in carbon tetrachloride‐induced liver injury in mice
Author(s) -
Mandal Pradyot K.,
Bishayee Anupam,
Chatterjee Malay
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070127
Subject(s) - carbon tetrachloride , albumin , globulin , microsome , urea , chemistry , pharmacology , stimulation , biochemistry , liver injury , medicine , enzyme , organic chemistry
Experiments were carried out to determine the efficacy of the Mikania cordata root extract in the tissue repair activities in mice intoxicated with carbon tetrachloride (CCl 4 ). We have estimated total plasma protein, albumin, globulin, blood urea, hepatic microsomal ribonucleic acid (RNA) and cytochrome P‐450 level. Acute single intraperitoneal administration of CCl 4 (1 mL of 20% v/v in olive oil/kg body weight) decreased albumin and increased globulin level and thereby reduced the albumin‐globulin ratio. A lower blood urea level was also noticed after treatment of mice with CCl 4 . A 1 h pretreatment with the root extract tended to reverse these features which were found to be dose‐dependent, but the results were statistically significant in the dose range of 100–150mg/kg. The M. cordata root extract (at 150mg/kg) dramatically improved the level of hepatic microsomal RNA (42.2%; p <0.001) and cytochrome P‐450 content (70.2%; p <0.001) that were altered in CCl 4 ‐induced liver damage. Based on these observations, it is considered that M. cordata root extract may alleviate the deleterious effects of CCl 4 , protect the liver cells and activate the hepatic reticuloendothelial system‐mediated defence mechanism as well as the regeneration of protein synthesis.