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Hepatitis B surface antigen (HBsAg) inactivation and angiotensin‐converting enzyme (ACE) inhibition in vitro by Combretum glutinosum perr. (Combretaceae) extract
Author(s) -
Pousset J. L.,
Rey J. P.,
Levesque J.,
Coursaget P.,
Galen F. X.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070126
Subject(s) - hbsag , combretaceae , decoction , traditional medicine , in vitro , enzyme , chemistry , antigen , gallic acid , pharmacology , biochemistry , hepatitis b virus , biology , medicine , virology , virus , immunology , antioxidant
Among the aqueous extracts of ten African medicinal plants traditionally used for the treatment of hepatic disease and which can inhibit hepatitis B virus antigen (HBsAg) in vitro , extracts from the leaf decoction of Combretum glutinosum proved to be the most active (100–500 ng/mL −1 ). With solvents of increasing polarity, a precipitate was isolated from the methanolic phase of this extract which contains gallic tannins and these compounds may be responsible for the effect on angiotensin‐converting enzyme (ACE).