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Experimental pharmacokinetics of biologically active plant phenolic compounds. II. Pharmacokinetics of likviritin in the rat
Author(s) -
Voskoboinikova I. V.,
Tjukavki. A.,
Kolhir V. K.,
Geodakyan S. V.,
Zjuzin V. A.,
Kolesnik Yu. A.,
Litvinenko V. I.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070120
Subject(s) - pharmacokinetics , urine , pharmacology , oral administration , chemistry , chromatography , biological activity , medicine , in vitro , biochemistry
A procedure was developed to measure plasma and urine likviritin levels by reversed‐phase high performance liquid chromatography. The likviritin pharmacokinetics was studied in rats after intravenous injection of the compound in a single dose of 1,3 and 10 mg/kg and after its oral administration in a single dose 50 and 500 rag/kg. It was shown that likviritin pharmacokinetics after i.v. injection within the above dose range was nonlinear and within every dose could be described by a two‐compartmental model. Its nonlinear nature might be associated with saturated binding of the compound.