Premium
Pharmacological study of phenylpropanoid glycosides: Platelet aggregation and blood pressure studies in rabbits and rats
Author(s) -
Capasso A.,
Pieretti S.,
Di Giannuario A.,
Nicoletti M.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070119
Subject(s) - platelet , phenylpropanoid , blood pressure , calcium , pharmacology , glycoside , chemistry , pharmacognosy , medicine , biochemistry , endocrinology , biological activity , enzyme , stereochemistry , biosynthesis , in vitro
The effects of phenylpropanoid glycosides (PhGs) isolated from Calceolaria and Orobanche on platelet aggregation and blood pressure have been investigated. The PhGs tested were able to interfere with platelet aggregation, producing pro‐ or antiaggregant effects. On the other hand, none of the PhGs tested had a significant effect on Mood pressure. The results suggest that the effects of PhGs on rabbit platelets may be related to a differential modulation of cAMP‐phosphodiesterase.