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Effects of ginsenoside‐Rb 2 on RNA synthesis
Author(s) -
Yokozawa T.,
Yasui T.,
Oura H.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070116
Subject(s) - orotic acid , rna , rna polymerase , microbiology and biotechnology , polymerase , chemistry , messenger rna , ginsenoside , biochemistry , biology , enzyme , medicine , gene , alternative medicine , pathology , ginseng
The effects of a single intraperitoneal injection of ginsenoside‐Rb 2 , 2.5 mg/100g body weight, on the synthesis of nuclear RNA in liver cells were determined serially after administration. Although the RNA content remained almost unchanged, the uptake of orotic acid by RNA reached a peak 6h after ginsenoside‐Rb 2 administration. On the other hand, the total RNA polymerase activity increased after administration, reaching a peak at 4h; the RNA polymerase II activity also showed a pattern of variation similar to that of total RNA polymerase activity. In addition, the activity of RNA polymerase I also showed an increase suggesting that ginsenoside‐Rb 2 promoted the synthesis of rRNA and mRNA.