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Pharmacological properties of a lyophilizate from Galeopsis ladanum on the central nervous system of rodents
Author(s) -
Czarnecki R.,
Librowski T.,
Zélbala K.,
Kohlmünzer S.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070104
Subject(s) - locomotor activity , central nervous system , caffeine , pharmacology , sedative , biological activity , amphetamine , motor activity , chemistry , biology , medicine , endocrinology , in vitro , biochemistry , dopamine
The influence of a fraction obtained from Galeopsis ladanum L. on the central nervous system of rodents was examined. The results of these investigations show that the fraction impeded CNS activity. It is practically nontoxic and at a dose of 2000 mg/kg i.p. it does not have a soporific influence on mice. It reduces considerably the spontaneous locomotor activity of mice as well as the locomotor activity of mice stimulated by caffeine, but did not influence the locomotor activity induced by amphetamine. The extract did not exhibit a synergetic effect with barbiturates. The results suggest that the pharmacological activity of the extract resembled the activity of drugs which generally depress the CNS, being on the border between ataractic and sedative drugs.