Premium
Experimental pharmacokinetics of biologically active plant phenolic compounds. I. Pharmacokinetics of mangiferin in the rat
Author(s) -
Geodakyan S. V.,
Voskoboinikova I. V.,
Tjukavki. A.,
Kolhir V. K.,
Kolesnik Yu. A.,
Zjuzin V. A.,
Glyzin V. I.,
Sokolov S. J.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060611
Subject(s) - mangiferin , pharmacokinetics , pharmacology , oral administration , chemistry , biological activity , drug , medicine , biochemistry , in vitro
The pharmacokinetics of mangiferin (the main component of the drug ‘Alpizarin’) was studied by HPLC in rats after intravenous injection of the drug in a single dose of 0.3, 1, 3, 10 and 30 mg/kg and after its oral administration in a single dose of 50–500 mg/kg. It was shown that the mangiferin pharmacokinetics for the above dose levels was nonlinear, and within each dose could be described by a two‐compartmental model. Its nonlinearity might be associated with saturated binding and metabolism of the compound.