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Effects of saponins from Mimosa tenuiflora on lymphoma cells and lymphocytes
Author(s) -
Jiang Yulin,
Weniger Bernard,
HaagBerrurier Micheline,
Anton Robert,
Beck JeanPaul,
Italiano Liliane
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060606
Subject(s) - splenocyte , in vitro , thymidine , cell culture , bark (sound) , biology , pharmacognosy , lymphoma , dna synthesis , traditional medicine , lymphocyte , microbiology and biotechnology , pharmacology , biological activity , biochemistry , immunology , medicine , ecology , genetics
The following saponosides: mimonosides A (Ma), B (Mb) and C (Me), isolated from the bark of Mimosa tenuiflora (Willd.) Poiret (Mimosaceae) were tested for their influence on cell growth. These effects were evaluated in vitro on a panel of lymphoma cells from human and murine origins and on murine lymphocytes (thymocytes and splenocytes). The three saponins did not exhibit any growth influence on two tumour cell lines (Molt 4 and RDM 4). However, they exhibit an important increase of incorporation of tritiated thymidine into DNA of cultured lymphocytes in vitro. Synergic effects of the saponins with concanavaline A (Con A) and lipopolysaccharide (LPS) on the lymphocytes were observed.