Premium
Antitumour activity of Ganoderma lucidum , an edible mushroom, on intraperitoneally implanted lewis lung carcinoma in synergenic mice
Author(s) -
Furusawa E.,
Chou S. C.,
Furusawa S.,
Hirazumi A.,
Dang Y.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060604
Subject(s) - lewis lung carcinoma , pharmacology , cytotoxic t cell , traditional medicine , ganoderma lucidum , medicine , cisplatin , phytotherapy , aqueous extract , pharmacognosy , methotrexate , mushroom , cytotoxicity , ratón , chemistry , biological activity , chemotherapy , in vitro , immunology , biochemistry , pathology , cancer , food science , metastasis , alternative medicine
The antitumour activity of Ganoderma lucidum , called ‘Ling‐Zhi or holy mushroom’in Chinese traditional medicine, was investigated on intraperitoneally implanted Lewis lung carcinoma in syngeneic C57BL/6 mice. An aqueous extract of Ling‐Zhi significantly increased the life span of tumour‐implanted mice, when administered intraperitoneally alone or in combination with cytotoxic antitumour drugs (Adriamycin, fluorouracil, thioguanine, methotrexate, Cisplatin) or a synthetic immunomodulator (Imexon). The aqueous extract was not cytotoxic in cell cultures and the antitumour activity was abolished by pretreatment of mice with cyclosporine. The active principle(s) was found to be present predominantly in the ethanol precipitable fraction of the aqueous extract.