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Cardiovascular effects in rodents of the methanolic extract of the stem bark of Khaya senegalensis A. Juss
Author(s) -
Olayinka A. O.,
Onoruvwe O.,
Lot T. Y.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060513
Subject(s) - chronotropic , isoprenaline , prazosin , khaya , propranolol , traditional medicine , pharmacology , bark (sound) , chemistry , pharmacognosy , contraction (grammar) , stimulation , heart rate , blood pressure , medicine , biology , biological activity , receptor , biochemistry , antagonist , ecology , in vitro
The methanolic bark extract of Khaya senegalensis was investigated for its effects on the cardiovascular system. The extract increased the blood pressure of chloralose anaesthetized rats. The increase in rate and force of contraction of isolated, spontaneous rabbit atria evoked by the extract were dose dependent and less pronounced than those produced by isoprenaline. The chronotropic effects of the extract and isoprenaline were antagonized by propranolol which also abolished the ionotropic effect of the extract and antagonized isoprenaline‐induced inotrophy. The vasoconstrictor effect of the extract observed with isolated spiral strips of rabbit aorta was dose dependent, less potent than noradrenaline and was abolished by prazosin. These findings indicate that the hypertensive effect of the methanolic bark extract of K. senegalensis is partly due to the stimulation of β‐receptors and α‐adrenoceptors.