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Hypocholesterolaemic and antiatherosclerotic effects of solasodine (C 27 H 42 O 2 N) in cholesterol fed rabbits
Author(s) -
Dixit V. P.,
Varma M.,
Mathur N. T.,
Mathur R.,
Sharma S.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060510
Subject(s) - solasodine , cholesterol , diosgenin , medicine , endocrinology , chemistry , aorta , biology , botany , solanum , organic chemistry
Solasodine (C 27 H 42 O 2 N), a nitrogen analogue of diosgenin reduced serum cholesterol and LDL cholesterol by 73.3% and 73.5% and prevented atherogenesis (Atherogenic index‐control: 1.99; athero‐ group: 3.12; solasodine treatment 2.12–2.32). The cholesterol/phospholipid ratio was decreased by 42.02% while the HDL ratio was raised significantly. Solasodine treatment prevented the accumulation of cholesterol in the liver and aorta and regressed plaque size in the thoracic and abdominal aorta. Faecal excretion of cholesterol and phospholipids was significantly ( p >0.001) increased suggesting that modulation of absorption was affected.