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Hypotensive effect and enzyme inhibition activity of mapuche medicinal plant extracts
Author(s) -
SchmedaHirschmann G.,
Loyola J. I.,
Sierra J.,
Retamal R.,
Rodriguez J.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060404
Subject(s) - xanthine oxidase , medicinal plants , traditional medicine , enzyme , biology , brine shrimp , pharmacognosy , enzyme assay , biological activity , ethnobotany , pharmacology , medicine , biochemistry , in vitro
Thirty‐five plant samples belonging to 30 Mapuche medicinal plants were assayed for xanthine oxidase and β‐glucuronidase inhibitory activity as well as for brine shrimp toxicity and hypotensive effect in normotensive rats. A high number of extracts displayed significant inhibition towards the enzyme β‐glucuronidase or elicited a hypotensive response. The biological activity of the assayed extracts shows some correlation with their use as digestives for treating hepatic troubles by the Mapuche Amerindians. From the ten plants displaying a hypotensive effect ≥20%, eight have some ethnobotanical indication suggesting that activity.