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Hypolipidaemic Activity in Rats of Bergenin, the Major Constituent of Flueggea microcarpa
Author(s) -
Jahromi M. A. Farboodniay,
Chansouria J. P. N.,
Ray Anil B.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060403
Subject(s) - bergenin , cholesterol , very low density lipoprotein , pharmacognosy , lipoprotein , endocrinology , oral administration , chemistry , medicine , high density lipoprotein , biology , biological activity , biochemistry , chromatography , in vitro
Oral administration of bergenin, isolated from the leaves of Flueggea microcarpa , to hyperlipidaemic rats for 14 days significantly decreased serum total lipid without much change in serum cholesterol and triglycerides. However, after 21 days of administration, the serum cholesterol, triglycerides, low‐density lipoprotein (LDL)—and very low‐density lipoprotein (VLDL)—cholesterol levels were significantly reduced while the serum high‐density lipoprotein (HDL)‐cholesterol level was elevated. Bergenin‐treated animals also showed a significant decrease in atherogenic index.