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Potentiating action of Datura metel Linn. Root extract on rat intestinal cholinesterase
Author(s) -
Prabhakar E.,
Kumar N. V. Nanda
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060314
Subject(s) - datura , cholinesterase , alkaloid , enzyme , substrate (aquarium) , chemistry , biology , traditional medicine , pharmacology , biochemistry , botany , medicine , ecology
Datura metel Linn. leaf extract which is known to contain scopolamine, a tropane alkaloid, was found to inhibit rat intestinal cholinesterase in vitro. The inhibition could not be reversed with higher concentrations of cholinesterase substrate. Whereas Dutura metel root extract was found to activate cholinesterase enzyme activity at optimal or higher substrate concentrations. With root and leaf extract together, the cholinesterase activity level at higher concentrations of substrate, was elevated compared with the inhibitory effect of Datura leaf extract alone, suggesting a potentiating action of Datura root extract on cholinesterase.