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Analgesic and antiinflammatory activity in acute and chronic conditions of Trema guineense (Schum. et Thonn.) Ficalho and Trema micrantha Blume extracts in rodents
Author(s) -
Barbera R.,
Trovato A.,
Rapisarda A.,
Ragusa S.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060309
Subject(s) - analgesic , traditional medicine , pharmacognosy , medicine , pharmacology , adjuvant , acetic acid , chemistry , biological activity , biochemistry , in vitro , immunology
Abstract The analgesic activity of extracts of Trema guineense (Schum. et Thonn.) Ficalho and Trema micrantha Blume were evaluated in mice by the acetic acid induced writhing test and in rats by the hot plate method. The antiinflammatory and antiarthritic activities were evaluated in rats by the carrageenin‐induced Oedema assay and Newbould's adjuvant arthritis test. Pharmacological activities were compared with indomethacin. The ether and ethanol extracts of both species showed a significant analgesic activity in both tests. As regards the antiinflammatory and antiarthritic activities, the ether extract of Trema micrantha (1 kg of dry leaves) produced the highest percentage of inhibition of carrageenin‐induced oedema and adjuvant arthritis and this effect was comparable to that of indomethacin.