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Pollen extracts reduce the hepatotoxicity of paracetamol in mice
Author(s) -
Juźwiak S.,
Raińska T.,
Dutkiewicz T.,
Cioch U.,
Olenderek B.,
Krasowska B.,
Rózewicka L.,
Juzyszyn Z.,
Wójcicki J.,
Samochowiec L.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060308
Subject(s) - glutathione , glycogen , alkaline phosphatase , bilirubin , liver injury , acute toxicity , pharmacology , toxicity , acetaminophen , liver toxicity , medicine , liver tissue , chemistry , biochemistry , enzyme
Abstract Cernitins are preparations obtained from plant pollen which contain numerous compounds of potential biological significance. This work deals with the influence of cernitins upon acute paracetamol toxicity in mice. The survival rate and indices of hepatic injury: aminotransferase and alkaline phosphatase activities, bilirubin level in serum, glutathione and cytochrome P‐450 content in liver, liver weight, histopathologic picture of the liver and presence of glycogen and lipids in stained liver sections, under different experimental protocols, were determined. It was found that cernitins are able to increase the survival rate of mice and reduce liver injury in acute paracetamol poisoning. Cernitins are more effective when administered after, rather than before, a dose of paracetamol. The possible mechanism through which cernitins may act is discussed.