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The effects of Baphia nitida Lodd (leguminosae) extract on the gastrointestinal tract of rats and mice
Author(s) -
Onwukaeme D. N.,
Lot T. Y.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060305
Subject(s) - atropine , histamine , traditional medicine , ranitidine , gastric emptying , pharmacognosy , pharmacology , stomach , gastrointestinal tract , guinea pig , antiemetic , chemistry , biology , medicine , gastroenterology , in vitro , biological activity , biochemistry , chemotherapy
The constituents from the leaves of Baphia nitida were extracted using methanol and acetone as solvents. The extract did not demonstrate any acute toxic effects in mice within the dose range used during this study. The extract inhibited gastric emptying time in rats and intestinal motility in mice, both effects were manifested in a dose‐related fashion. These effects were similar but less pronounced than those produced by atropine sulphate. The extract did not induce gastric ulceration in rats and failed to protect against acetyl salicylic acid‐induced gastric ulcer in rats or histamine‐induced duodenal ulcer in guinea‐pigs.