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Studies on the antiulcerogenic activity of the essential oil of Hyptis mutabilis Briq. in Rats
Author(s) -
Barbosa P. P. P.,
Ramos C. P.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060214
Subject(s) - traditional medicine , essential oil , subcutaneous injection , pharmacognosy , mechanism of action , pharmacology , chemistry , medicine , botany , biology , biological activity , biochemistry , in vitro
The volatile oil of Hyptis mutabilis , Briq. was investigated for its ability to prevent or reduce the formation of ulcerations in the gastric mucosa of male rats induced by indomethacin subcutaneous injection. When previously administered (p.o. and i.p.) the oil (F1473; 50–100 mg/kg) significantly reduced gastric alterations produced by indomethacin in a dose‐dependent fashion. However, the mechanism of action of this plant oil is still unkown.