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Inhibition of ethyl phenylpropiolate‐induced rat ear oedema by compounds isolated from Ipomoea pes‐caprae (L.) R. Br.
Author(s) -
Pongprayoon U.,
Bohlin L.,
Baeckström P.,
Jacobsson U.,
Lindström M.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060211
Subject(s) - eugenol , ipomoea , antispasmodic , phytol , bioassay , traditional medicine , prostaglandin , fractionation , in vitro , stereochemistry , biology , biological activity , chemistry , pharmacology , biochemistry , botany , chromatography , medicine , organic chemistry , genetics
The extract (IPA) of leaves from Ipomoea pes‐caprae (L.) R. Br. has previously been shown to reduce the development of rat ear oedema induced by ethyl phenylpropiolate (EPP) in a dose‐dependent manner. Using this bioassay to guide fractionation of the extract, two diastereomeric compounds, the actinidols 1a and 1b, were isolated (0.8% of IPA). The actinidols constitute part of the active principle of IPA. Compounds, previously isolated from IPA, with either prostaglandin synthesis inhibiting activity in vitro [2‐hydroxy‐4,4,7‐trimethyl‐1(4H)‐naphthalenone, (−)‐mellein and eugenol] or antispasmodic activity (E‐phytol) were also assayed for inhibitory effects on the development of EPP‐induced rat ear oedema. They all reduced oedema formation dose‐dependently. The results suggest that IPA consists of several active compounds which interfere with the process of inflammation in different ways.