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Activity of delphinidin on microvascular damage models in rodents
Author(s) -
Conti M.,
Cristoni A.,
Magistretti M. J.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060210
Subject(s) - histamine , vascular permeability , delphinidin , medicine , hyaluronidase , pharmacology , intraperitoneal injection , oral administration , chemistry , biochemistry , antioxidant , enzyme , cyanidin
Delphinidin chloride (IdB 1056) was found to possess a significant activity by the intraperitoneal and oral routes in different experimental models of microvascular damage. It antagonized the increase in skin capillary permeability induced by histamine in rats and rabbits, by bradykinin and hyaluronidase in rats and by xylol in mice. Significant increases in skin capillary resistance were observed after a 3‐day oral dosing in guinea‐pigs and rats. A significant enhancement in cutaneous wound healing rate was found with a 10‐day oral treatment in rats made locally ischaemic. Delphinidin showed a low acute toxicity by the oral route.