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Reversal of thioacetamide induced cholestasis by picroliv in rodents
Author(s) -
Shukla B.,
Visen P. K. S.,
Patnaik G. K.,
Dhawan B. N.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060114
Subject(s) - thioacetamide , cholestasis , pharmacology , chemistry , bile acid , medicine , biochemistry
Abstract Thioacetamide (100 and 200 mg/kg s.c.) reduced the volume of bile secretion by 33.1–50.6% and this was accompanied by a reduction in bile acids (31–54%) and bile salts (60–61%) in conscious rats and anaesthetized guinea‐pigs. A significant reversal of these effects was achieved by pretreatment with picroliv, the hepato‐protective principle of Picrorhiza kurrooa , in a dose dependent manner against thioacetamide‐induced cholestasis. Picroliv was found to be more active than silymarin in both experimental models of cholestasis.