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Hepatoprotective activity of Hypericum perforatum L. alcoholic extract in rodents
Author(s) -
Öztürk Y.,
Aydin S.,
Başer K. H. C.,
Kirimer N.,
KurtarÖztürk N.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060111
Subject(s) - hypericum perforatum , choleretic , hepatoprotection , hypericin , pharmacology , traditional medicine , bile duct , hypericum , medicine , chemistry , biochemistry , enzyme , glutathione
In recent years, interest in the hepatoprotective plants and plant based chemicals is increasing. In Turkish folk medicine, Hypericum perforatum L. has been used for various purposes including liver protection. The hepatoprotective effect of H. perforatum was investigated in vivo by cannulating the rat bile duct for choleretic activity and by barbiturate sleeping time following CCI 4 ‐induced hepatic injury. The increase in the bile secretion following intraduodenal injection of H. perforatum extract, and the appearance of its constituents in the bile were observed by its colour change and this observation was confirmed by thin layer chromatographic analysis suggesting the excretion of hypericin into the bile as well. It was observed that the extract shortens the barbiturate sleeping time of CCI 4 ‐treated mice suggesting hepatoprotection.