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Studies on capsaicin inhibition of chemically induced lipid peroxidation in the lung and liver tissues of rat
Author(s) -
De Amit Krishna,
Ghosh Jagat Jiban
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060109
Subject(s) - capsaicin , microsome , chemistry , in vivo , lipid peroxidation , carbon tetrachloride , in vitro , biochemistry , pharmacology , microsoma , mitochondrion , enzyme , biology , receptor , microbiology and biotechnology , organic chemistry
Previous work from this laboratory has already indicated that capsaicin, stabilizes the rat lung membrane lipid system on long‐term treatment. This stabilization of the membrane is further supported by our present findings that capsaicin pretreatment causes significant inhibition of various chemically induced lipid peroxidative changes at both cellular and subcellular levels. Both in vivo and in vitro studies, using whole lung and liver tissue slices and mitochondrial and microsomal fractions, have shown that capsaicin pretreatment inhibits peroxidative changes at both cellular and subcellular levels. Both in vivo and in vitro studies, using whole lung and liver tissue slices and mitochondrial and microsomal fractions, have shown that capsaicin pretreatment inhibits peroxidative changes induced by different chemical irritants such as chloroform, dichloromethane, carbon tetrachloride as well as ferrous sulphate.