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Antiimplantation mechanism of action of embelin in rats
Author(s) -
Prakash Anand O.,
Sisodia Bhavna,
Mathur R.
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060108
Subject(s) - decidualization , uterus , ovary , apposition , stimulation , mechanism of action , endocrinology , medicine , in utero , pharmacology , chemistry , biology , in vitro , pregnancy , biochemistry , fetus , genetics
The antiimplantation mechanism of action of embelin has been studied in rats. Its administration caused a significant reduction in ovarian and uterine wet weight. Ovarian histology revealed newly formed corpora lutea and the biochemical constituents were decreased. Similarly, the uterus of pregnant treated rats did not show any preparative changes, decidualization, apposition reaction, stimulation or proliferation. Biochemical constituents also behaved as those of cyclic rats even on the day of implantation. These findings suggest that the administration of embelin to pregnant rats keeps the ovary and uterus in a cyclic condition.