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Cytotoxic and antitumour activity of scopadulcic acid from Scoparia dulcis L.
Author(s) -
Hayashi Kyoko,
Hayashi Toshimitsu,
Morita Naokata
Publication year - 1992
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650060103
Subject(s) - traditional medicine , pharmacognosy , cytotoxic t cell , chemistry , medicine , biological activity , in vitro , biochemistry
Scopadulcic acid B is a diterpenoid recently isolated from Scoparia dulcis L. This compound showed greater cytotoxicity against cell lines derived from tumour tissues with a 50% inhibitory concentration (IC 50 ) of 0.068–0.076 μg/mL, compared with cell lines from normal tissues with an IC 50 of 0.097–0.245 μg/mL. The in vivo antitumour activity of scopadulcic acid B was determined using mice inoculated with Ehrlich ascites tumour cells. Oral administration of the compound at doses of 25 or 100 mg/kg/day prolonged the median survival time of the animals. However, when administered intraperitoneally to mice at doses of 25, 50 or 100 mg/kg/day, scopadulcic acid B increased the survival rate by 12.5%, 12.5% and 25%, respectively, without weight change over the treatment period.