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Antidiarrhoeic activity of Sclerocarya birrea bark extract and its active tannin constituent in rats
Author(s) -
Galvez J.,
Zarzuelo A.,
Crespo M. E.,
Utrilla M. P.,
Jiménez J.,
Spiessens C.,
de Witte P.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050611
Subject(s) - tannin , bark (sound) , decoction , laxative , traditional medicine , chemistry , pharmacognosy , proanthocyanidin , sodium , biological activity , pharmacology , biochemistry , medicine , food science , in vitro , biology , polyphenol , organic chemistry , ecology , constipation , antioxidant
The antidiarrhoeic activity of the bark of Sclerocarya birrea was investigated. The lyophilized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by magnesium sulphate and sodium picosulphate. This antidiarrhoeic activity was related to an inhibition of intestinal transit rather than to inhibition of net secretion of fluid and electrolytes provoked by the laxative agents. A condensed tannin was isolated from the crude drug which produced inhibition in intestinal motility, and the monomer of which was identified as procyanidin.