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Effect of condensed tannins and related compounds on reverse transcriptase
Author(s) -
Kakiuchi Nobuko,
Kusumoto Ines T.,
Hattori Masao,
Namba Tsuneo,
Hatano Tsutomu,
Okuda Takuo
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050609
Subject(s) - trimer , reverse transcriptase , tetramer , primer (cosmetics) , proanthocyanidin , chemistry , stereochemistry , rna , monomer , enzyme , biochemistry , dimer , polyphenol , organic chemistry , antioxidant , gene , polymer
Inhibitory effects of 18 condensed tannins and related compounds on reverse transcriptase from an RNA tumour virus were examined in the presence of poly(riboadenylic acid) oligo(deoxythymidylic acid) ((rA) n (dT) 12–18 ) or poly(ribocytidylic acid) oligo(deoxyguanylic acid) ((rC) n (dG) 12–18 ) as a template‐primer. A potent inhibitory effect was found in galloylated monomers and oligomers as well as non‐galloylated tetramer, trimer and two of three dimers. The mode of the inhibition of one of them, procyanidin B‐2, was competitive with regard to the template‐primer.