Premium
Studies on plant resources, pharmacology and clinical treatment with berbamine
Author(s) -
Liu ChangXiao,
Xiao PeiGen,
Liu GuoSheng
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050508
Subject(s) - pharmacology , medicine , leukopenia , chemotherapy , phytotherapy , drug , clinical pharmacology , adjuvant , pathology , alternative medicine
In the present paper, the plant resources, chemistry, pharmacology and clinical therapy of berbamine are reported. From a botanical survey it was found that there are 32 species of Berberis plants containing berbamine utilized in China. Pharmacological studies demonstrated that berbamine possesses significant leukogenic effects in rats and dogs injured by an anticancer agent, and clinical observations demonstrated a therapeutic effect in 405 patients with leukopenia. It is suggested that berbamine may not only be useful as a leukogenic drug but is also useful as an adjuvant in cancer chemotherapy and radiotherapy.