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Effects of naringenin and silymarin on urinary excretion of water and electrolytes in rats
Author(s) -
Alarc de la Lastra C. Ón,
Martín M. J.,
Motilva V.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050413
Subject(s) - naringenin , diuretic , furosemide , kaliuresis , chemistry , excretion , potassium , sodium , pharmacology , endocrinology , medicine , urinary system , flavonoid , natriuresis , biochemistry , antioxidant , organic chemistry
The effects of two flavonoid derivatives, naringenin and silymarin on urinary excretion of water and electrolytes were investigated in isotonic saline loaded rats. Both compounds, especially naringenin, showed a moderate diuretic activity, in comparison with furosemide, increasing significantly the renal loss of sodium, chloride and potassium. With respect to silymarin, although urinary excretion was significantly lower, it caused a marked decrease in potassium excretion. These results indicate that naringenin has a diuretic behaviour similar to moderate‐efficiency diuretic agents and silymarin to potassium‐sparing diuretics.