Effects of naringenin and silymarin on urinary excretion of water and electrolytes in rats | Zendy

Alarc de la Lastra C. Ón | Zendy; Martín M. J. | Zendy; Motilva V. | Zendy

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Effects of naringenin and silymarin on urinary excretion of water and electrolytes in rats

Author(s) -

Alarc de la Lastra C. Ón,

Martín M. J.,

Motilva V.

Publication year - 1991

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650050413

Subject(s) - naringenin , diuretic , furosemide , kaliuresis , chemistry , excretion , potassium , sodium , pharmacology , endocrinology , medicine , urinary system , flavonoid , natriuresis , biochemistry , antioxidant , organic chemistry

The effects of two flavonoid derivatives, naringenin and silymarin on urinary excretion of water and electrolytes were investigated in isotonic saline loaded rats. Both compounds, especially naringenin, showed a moderate diuretic activity, in comparison with furosemide, increasing significantly the renal loss of sodium, chloride and potassium. With respect to silymarin, although urinary excretion was significantly lower, it caused a marked decrease in potassium excretion. These results indicate that naringenin has a diuretic behaviour similar to moderate‐efficiency diuretic agents and silymarin to potassium‐sparing diuretics.

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