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Antiinflammatory and anti‐ulcerogenic activities of the organic extracts of Tanacetum microphyllum DC. in rats
Author(s) -
Abad M. J.,
Bermejo P.,
Villar A.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050409
Subject(s) - dichloromethane , traditional medicine , pharmacognosy , oral administration , carrageenan , ethyl acetate , pharmacology , chemistry , diterpene , biological activity , medicine , biochemistry , solvent , in vitro
Extracts of Tanacetum microphyllum DC. (Compositae) have been investigated for antiinflammatory and anti‐ulcerogenic activity in the rat. In adjuvant‐carrageenan‐induced inflammation (ACII), orally administered organic extracts of T. microphyllum (hexane, dichloromethane, ethyl acetate and methanol) inhibited both the acute and chronic phases of this experimental model of inflammation, but mainly the chronic phase; the dichloromethane extract was as effective as phenylbutazone. Prior oral administration of T. microphyllum organic extracts prevented the ulcerogenic effect of orally administered indomethacin. Again, the dichloromethane extract exhibited the greatest activity.