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Antifungal flavonoids from Varthemia iphionoides
Author(s) -
Afifi F. Ü.,
AlKhalil S.,
AbdulHaq B. K.,
Mahasneh A.,
AlEisawi D. M.,
Sharaf M.,
Wong L. K.,
Schiff P. L.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050407
Subject(s) - bacillus cereus , candida tropicalis , microbiology and biotechnology , fusarium solani , staphylococcus aureus , biology , aspergillus parasiticus , antifungal , bacteria , traditional medicine , aspergillus , chemistry , medicine , genetics
Four flavonoids 5,7,4′‐trihydroxy‐3,3′‐dimethoxyflavone (3′,3′‐di‐ O ‐methylquercetin) (1), 5,4′‐dihydroxy‐3,7‐dimethoxyflavone (kumatakenin) (2), 5,4′‐dihydroxy‐6,7,8,‐trimethoxyflavone (xanthomicrol) (3) and 5,7,4′‐trihydroxy‐3,6,3′‐trimethoxyflavone (jaceidine) (4) were isolated and identified from the Jordanian Varthemia iphionoides . They have not previously been reported in this genus. The aqueous alkaline solution of these compounds showed little or no activity against the bacteria Staphylococcus aureus, Bacillus cereus and Salmonella typhimurium . Compound 2 was active against the fungi Fusarium solani and Candida tropicalis while compounds 1 and 3 were much more active against F. solani, Aspergillus parasiticus and C. tropicalis .