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Inhibitory effects of the sesquiterpene T‐cadinol on contractile responses in the isolated guinea‐pig ileum
Author(s) -
Zygmunt Peter,
Claeson Per
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050312
Subject(s) - carbachol , histamine , ileum , guinea pig , contraction (grammar) , biology , inhibitory postsynaptic potential , receptor , chemistry , pharmacology , biochemistry , endocrinology
The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba 2+ and K + in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba 2+ ‐ and K + were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four spasmogens.