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Prevention of paracetamol‐induced hepatic damage in rats by picroliv, the standardized active fraction from Picrorhiza kurroa
Author(s) -
Dwivedi Yogesh,
Rastogi Ravi,
Garg N. K.,
Dhawan B. N.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050306
Subject(s) - alkaline phosphatase , pharmacology , bilirubin , chemistry , oral administration , glycogen , hepatoprotection , biochemistry , medicine , endocrinology , enzyme , glutathione
Abstract Single oral administration of paracetamol (2 g/kg body wt) to rats caused significant changes in the activities of γ‐glutamyl transpeptidase, 5′‐nucleotidase, succinate dehydrogenase, glucose‐6‐phosphatase and cytochrome P 450 and contents of glycogen and cholesterol in liver after 24 and 48 h. Total lipids and lipid peroxides in liver increased both at 24 and 48 h while protein content of liver decreased after 48 h. Levels of transaminases, alkaline phosphatase and bilirubin in serum also increased. The magnitude of these changes was more after 48 h of paracetamol administration. Picroliv, the iridoid glycoside fraction of Picrorhiza kurroa , when given orally to rats (6 and 12 mg/kg body wt for 7 days) caused significant reversal of the paracetamol‐induced biochemical changes. The degree of protection at the two doses of picroliv was almost similar.