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Withania somnifera extract. Its effect on arterial blood pressure in anaesthetized dogs
Author(s) -
Ahumada F.,
Aspee F.,
Wikman G.,
Hancke J.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050305
Subject(s) - withania somnifera , blood pressure , pentobarbital , medicine , anesthesia , pharmacology , hemodynamics , saline , pathology , alternative medicine
The effect of Withania somnifera extract on arterial blood pressure in ‘normotensive’ pentobarbital anaesthetized dogs was studied. Also a possible effect of Withania somnifera on blood pressure in dogs administered either with adrenaline and acetylcholine was investigated. Thirty mongrel dogs of both sexes were distributed randomly in three series of ten animals each. Each animal was adminstered at intervals of 4 min with either a neurotransmitter, saline or the extract until a cycle of 32 minutes was completed. It is concluded that the Withania somnifera extract induced a significant decrease ( p < 0.05) in the arterial and diastolic blood pressure in ‘normotensive’ pentobarbital anaesthetized dogs. Withania also significantly prevented the hypotensive effect of acetyltholine and increased the hypertensive effect of adrenaline.