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Antiinflammatory activity of sesquiterpene lactones from Artemisia barrelieri in rats
Author(s) -
ZafraPolo M. C.,
Blázquez M. A.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050212
Subject(s) - sesquiterpene , artemisia , sesquiterpene lactone , lactone , chemistry , carrageenan , stereochemistry , methylene , traditional medicine , asteraceae , acetic acid , biology , botany , medicine , organic chemistry , biochemistry
Three eudesmanolides, barrelierin (1), artemalin (2) and barrelin (3), isolated from aerial parts of Artemisia barrelieri , and desoxyvulgarin (4) obtained from barrelin by reduction with zinc and acetic acid, reduced carrageenan‐induced rat paw oedema. The results show that the α‐methylene γ‐lactone group is not essential for the antiinflammatory effect, but variations in the molecular structure of these sesquiterpene lactones may enhance or diminish the antiinflammatory effect.