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Pharmacological evidence for a spasmogenic agent in Datura root extract tested on dispersed smooth muscle cells of guinea‐pig ileum
Author(s) -
Kumar N. V. Nanda,
Prabhakar E.,
Murthy K. Srinivasa
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050112
Subject(s) - datura , scopolamine , datura stramonium , acetylcholine , ileum , contraction (grammar) , guinea pig , biology , traditional medicine , botany , pharmacology , medicine , biochemistry , endocrinology
The effect of acetylcholine, scopolamine, and Datura leaf and root extracts on the contractility of dispersed muscle cells of guinea‐pig ileum was studied. Scopolamine and crude Datura leaf extract alone or together had no significant effect on contraction of smooth muscle cells. Acetylcholine and Datura root extract either alone or together caused a significant (30%) contraction. Datura root extract reversed the effect of both scopolamine and Datura leaf extract suggesting the presence of an unknown spasmogenic factor in Datura root extract.