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Pharmacological effects of rutin
Author(s) -
YildizoǧluAri Nuray,
Altan V. Melih,
Altinkurt Orhan,
Öztürk Yusuf
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050106
Subject(s) - rutin , antagonism , in vivo , pharmacology , chemistry , oral administration , respiratory tract , in vitro , medicine , biology , respiratory system , biochemistry , antioxidant , receptor , microbiology and biotechnology
It is well‐known that flavonoids including rutin exert a wide range of pharmacological effects. This study was carried out for further characterization of the pharmacological effect of rutin. A significant rise in the serum 5‐HT levels was found 2 h after the administration of rutin (25 mg kg −1 i.p.). The same dose of rutin caused no significant change in the serum 5‐hydroxytryptomine levels after 8 and 72 h when compared to controls. In the in vivo experiments, rutin (25 mg kg −1 i.p.) was ineffective on the blood pressure and respiratory tract of the guinea‐pigs in spite of its smooth muscle relaxant effects in the in vitro preparations. These findings strongly suggest a physiological antagonism in the effects of rutin in intact animals.