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Comparative antiarrhythmic and anti‐ischaemic activity of some flavones in the guinea‐pig and rat
Author(s) -
Occhiuto F.,
Busa G.,
Ragusa S.,
de Pasquale A.
Publication year - 1991
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650050104
Subject(s) - flavones , guinea pig , medicine , verapamil , vitexin , luteolin , pharmacology , ergonovine , apigenin , cardiology , flavonoid , myocardial infarction , chemistry , angina , biochemistry , antioxidant , chromatography , calcium
A comparative study of 16 flavones was carried out using 4 experimental models: 1, hyperkinetic ventricular arrhythmias induced by reperfusion in rat isolated heart; 2, arrhythmias following coronary artery ligation‐reperfusion in anaesthetized guinea‐pig; 3, pytressine arrhythmias by coronary spasm in anaesthetized guinea‐pig; and 4, anti‐ischaemic activity using an ex vivo perfusion heart technique after coronary occlusion in guinea‐pig. The structure effect relationships of flavone, 3‐hydroxyflavone, 6‐hydroxyflavone, 7‐hydroxyflavone, 6,7‐dihydroxyflavone, 7,8‐dihydroxyflavone, apigenin, apiin, diosmin, 5‐hydroxyflavone, luteolin, luteolin glycoside, orientin, pratol, rhoifolin, vitexin, tested as antiarrhythmic and anti‐ischaemic agents were compared to lidocaine and verapamil at equimolar doses. The results obtained demonstrated that most of these compounds exerted a protective effect against coronary‐spasm and coronary‐ligation induced ischaemic crisis, and against the ischaemic and the post‐ischaemic arrhythmias. The potencies were found to be structurally dependent for the flavones tested.