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The protective and curative action of Withania frutescens leaf extract against CCl 4 ‐induced hepatotoxicity
Author(s) -
Montilla M. P.,
Cabo J.,
Navarro M. C.,
Risco S.,
Jiménez J.,
Aneiros J.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040603
Subject(s) - traditional medicine , pharmacology , medicine , liver injury , histopathological examination , pathology
We studied the protective and curative action of an ethanol extract of Withania frutescens leaves against CCl 4 ‐induced hepatotoxicity. Hepatoprotective activity was evaluated in terms of the LD 50 of CCl 4 , the modification of Nembutal‐induced sleep, the action on bile flow, serum transaminase and hepatic fatty acids levels and a histopathological study of liver tissue. Curative action was assessed by measuring the duration of Nembutal‐induced sleep and with a histopathological study of liver tisue. The findings indicate that the leaf extract has both preventative and curative activity against CCL 4 ‐induced liver damage.