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Oral hypoglycemic effect of Salacia reticulata in the streptozotocin induced diabetic rat
Author(s) -
Serasinghe Soma,
Serasinghe Palitha,
Yamazaki Hiromi,
Nishiguchi Keiko,
Hombhanje Francis,
Nakanishi Suehiro,
Sawa Kazuko,
Hattori Masao,
Namba Tsuneo
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040511
Subject(s) - streptozotocin , oral administration , plasma glucose , diabetes mellitus , medicine , pharmacology , drug , traditional medicine , aqueous extract , endocrinology
The oral hypoglycemic activity of Salacia reticulata extract was evaluated in streptozotocin induced diabetic rats. The diabetic rats were orally administered an aqueous extract of Salacia reticulata and the plasma glucose concentration was determined at regular intervals following administration. The drug was effective as a hypoglycemic agent at all the doses tested (0.5 g/kg, 1.0 g/kg and 5.0 g/kg). The maximum percentage decrease in plasma glucose was observed between 1–5h following administration of the drug.