Premium
In vitro antimalarial activity of crude extracts and compounds from Artemisia abrotanum L
Author(s) -
Cubukcu B.,
Bray D. H.,
Warhurst D. C.,
Mericli A. H.,
Ozhatay N.,
Sariyar G.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040510
Subject(s) - artemisia , traditional medicine , plasmodium falciparum , pharmacognosy , sesquiterpene , hypoxanthine , in vitro , artemisinin , terpenoid , chemistry , biology , malaria , botany , biological activity , medicine , biochemistry , enzyme , immunology
Artemisia abrotanum L. (Compositae) is widely used in European herbal medicine for treatment of various ailments including fever. Crude extracts of this plant and some of their constituents were tested for antimalarial activity against Plasmodium falciparum in vitro using the technique of [ 3 H]hypoxanthine incorporation. Two pure compounds, isofraxidin and a novel sesquiterpene, 1(S*)‐hydroxy‐α‐bisabololoxide A acetate were found to be active (IC 50 values of 7.95 and 5.09 m̈g/mL, respectively).