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Protection afforded by aqueous extracts of Phyllanthus species against cytotoxicity induced by lead and aluminium salts
Author(s) -
Dhir Haimanti,
Roy Ajoy Kumar,
Sharma Archana,
Talukder Geeta
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040503
Subject(s) - phyllanthus emblica , cytotoxicity , clastogen , aluminium nitrate , chemistry , aqueous solution , antimutagen , phyllanthus , pharmacognosy , aqueous extract , aluminium , traditional medicine , silver nitrate , toxicity , pharmacology , nuclear chemistry , biology , biochemistry , mutagen , biological activity , in vitro , medicine , organic chemistry , genotoxicity , dna
Oral administration of aqueous extracts of Phyllanthus emblica L. fruit and P. niruri L. leaves to laboratory bred albino mice for a week, significantly reduced the cytotoxic action of lead nitrate and aluminium sulphate. The frequency of chromosomal breakages, gaps and rearrangements induced by three concentrations of these salts was decreased when compared to the control animals which had received the salts alone. The plant extracts were equally effective in modifying the clastogenic effects of both lead nitrate and aluminium sulphate.