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Antifilarial activity of Argyria speciosa against Setaria cervi in vitro
Author(s) -
Parveen Nazneen,
Khan Nizam U.,
Singhal K. C.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040409
Subject(s) - in vitro , aqueous extract , chemistry , pharmacology , traditional medicine , biology , medicine , biochemistry
The effect of aqueous and alcoholic extracts of Argyria speciosa on the spontaneous movements of both the whole worm and a nerve/muscle preparation of Setaria cervi , and on the survival of microfilariae in vitro , was studied. Both extracts caused the inhibition of spontaneous movements of the whole worm and the nerve/muscle preparation of S. cervi , characterized by decrease in tone, amplitude and rate of contractions. The concentration required to inhibit the movements of the whole worm preparation was 150 μg/mL for the aqueous, and 75 μg/mL for the alcoholic extract. The concentration of A. speciosa extract required to produce an equivalent effect on the nerve/muscle preparation was 25 μg/mL for aqueous, and 50 ng/mL for the alcoholic extract.