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Study of antihepatotoxicity of Eupatorium cannabinum L. in mice. An adequate method of screening in vivo antihepatotoxic natural principles
Author(s) -
Lexa A.,
Fleurentin J.,
Younos C.,
Mortiert F.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040405
Subject(s) - in vivo , aqueous extract , traditional medicine , lactone , medicine , pharmacology , chemistry , biology , stereochemistry , microbiology and biotechnology
An adequate model to test in vivo antihepatotoxic properties of aqueous extract of E. cannabinum and, in extension, of other natural compounds, is presented using mice. The aqueous extract was administered before and after CCI 4 intoxication: it decreased the ALAT plasmatic level in pretreatment but it is not efficient in post‐treatment. Eupatoriopicrin, the major sesquiterpenic lactone of the plant was not antihepatoxic at the dose contained in the extract.