Premium
Olea europaea L. and oleuropein: Effects on excito‐conduction and on monophasic action potential in anaesthetized dogs
Author(s) -
Occhiuto F.,
Circosta C.,
Gregorio A.,
Busa G.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040403
Subject(s) - repolarization , olea , cardiology , medicine , electrophysiology , torsades de pointes , anesthesia , oleuropein , chemistry , qt interval , biology , botany , biochemistry , antioxidant
The effects of a glyceroethanolic macerate of the leaves of Olea europaea L. and of oleuropein on excito‐conduction and on the right atrial and ventricular monophasic action potential (MAP) have been studied in anaesthetized dogs using the technique of endocavitary recording. At the higher doses tested, a slight increase in the sinusal cycle of the sinoatrial conduction time and of the sinus node recovery time, together with a prolongation of the atrioventricular and intraventricular conduction and an increase of the atrial and ventricular MAP duration were observed. This may be due to a decrease in the repolarization phase 3. These electrophysiological effects indicate an inhibitory action both on the swift influx of sodium and on the slow influx of calcium, as well as a decrease in potassium conductance.