Premium
Wogonin, 5,7‐dihydroxy‐8‐methoxyflavone as oestrogenic and anti‐implantational agent in the rat
Author(s) -
Singh Pahup,
Jain Sunita,
Bhala Manju,
Goyal Ravi Bala,
Jayaprakash D.,
Lohiya Nirmal K.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040303
Subject(s) - wogonin , bioassay , resorption , endocrinology , pharmacology , medicine , body weight , pregnancy , biology , andrology , scutellaria baicalensis , pathology , alternative medicine , traditional chinese medicine , genetics
Wogonin, 5,7‐dihydroxy‐8‐methoxyflavone, extracted from Holmskioldia sanguinea Retz. has been tested for oestrogenic and anti‐implantational activities in the rat. Wogonin displayed mild oestrogenic but effective anti‐implantational activities. In the three days uterotrophic bioassay, at a dose level of 10 mg/kg body weight per day, intramuscularly, the wet uterine and vaginal weights increased significantly. Wogonin at the same dose level when given intramuscularly from days 1–3, 4–6, 1–7 post coitum and orally from days 1–7 post coitum effectively inhibited implantation. However, when the drug was administered from days 7–9 post coitum , it did not affect the implantation, but interfered with normal development of the embryos which resulted in the resorption of foetuses. Wogonin, a mild oestrogenic compound, exhibited interceptory activity at all the stages of pregnancy.