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The antimalarial activity of chromatographic fractions of Spathodea campanulata stem bark extracts against Plasmodium berghei berghei in mice
Author(s) -
Makindet J. M.,
Amusan O. O. G.,
Adesogan E. K.
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040204
Subject(s) - plasmodium berghei , chromatography , traditional medicine , chemistry , column chromatography , chloroquine , bark (sound) , biology , medicine , malaria , ecology , immunology
Abstract Extracts of the stem bark of Spathodea campanulata which showed blood schizontocidal action were purified by column chromatography. The action of the fractions was studied using Fink and Kretschmar and Rane tests with chloroquine as reference drug. Column chromatography was effective for isolating the fractions responsible for the antimalarial property of the crude extracts. Some chromatographic fractions demonstrated significant antimalarial activity which was higher than that observed with the crude extracts.