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Comparative studies on the involvement of histamine and substance P in the inflammatory response of capsaicin in rat paw
Author(s) -
de Krishna Amit,
Ghosh Jagat Jiban
Publication year - 1990
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650040111
Subject(s) - capsaicin , histamine , substance p , nk1 receptor antagonist , antagonist , pharmacology , chemistry , medicine , endocrinology , receptor , neuropeptide
Direct administration of capsaicin (isolated from Capsicum frutescens ) in the rat paw caused a dose‐related inflammatory response, which reached a maximum peak within 10 min and remained steady for 180 min after injection. Pretreatment with histamine H 1 receptor antagonist and substance P antagonist produced significant inhibition to this capsaicin‐induced paw oedema. Results indicate the involvement of histamine in the early phase and both histamine and substance P in the later phase of capsaicin‐induced inflammation in the rat paw.