Comparative studies on the involvement of histamine and substance P in the inflammatory response of capsaicin in rat paw | Zendy

de Krishna Amit | Zendy; Ghosh Jagat Jiban | Zendy

Premium

Comparative studies on the involvement of histamine and substance P in the inflammatory response of capsaicin in rat paw

Author(s) -

de Krishna Amit,

Ghosh Jagat Jiban

Publication year - 1990

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650040111

Subject(s) - capsaicin , histamine , substance p , nk1 receptor antagonist , antagonist , pharmacology , chemistry , medicine , endocrinology , receptor , neuropeptide

Direct administration of capsaicin (isolated from Capsicum frutescens ) in the rat paw caused a dose‐related inflammatory response, which reached a maximum peak within 10 min and remained steady for 180 min after injection. Pretreatment with histamine H 1 receptor antagonist and substance P antagonist produced significant inhibition to this capsaicin‐induced paw oedema. Results indicate the involvement of histamine in the early phase and both histamine and substance P in the later phase of capsaicin‐induced inflammation in the rat paw.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research